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Article

Copper-based pulsed dipolar ESR spectroscopy as a probe of protein conformation linked to disease states.

Biophysical journal - 7 Oct 2014

Merz Gregory E, Borbat Peter P, Pratt Ashley J, Getzoff Elizabeth D, Freed Jack H, Crane Brian R

Abstract excerpt

We demonstrate the ability of pulsed dipolar electron spin resonance (ESR) spectroscopy (PDS) to report on the conformation of Cu-Zn superoxide dismutase (SOD1) through the sensitive measurement of dipolar interactions between inherent Cu(2+) ions. Although the extent and the anisotropy of the Cu ESR spectrum provides challenges for PDS, Ku-band (17.3 GHz) double electron-electron resonance and double-quantum...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25296320
DOI: 10.1016/j.bpj.2014.07.068
PMCID: PMC4190658

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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