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Article

A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop.

The Journal of biological chemistry - 6 Nov 2009

Molnar Kathleen S, Karabacak N Murat, Johnson Joshua L, Wang Qi, Tiwari Ashutosh, Hayward Lawrence J, Coales Stephen J, Hamuro Yoshitomo, Agar Jeffrey N

Abstract excerpt

At least 119 mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis by an unidentified toxic gain of function. We compared the dynamic properties of 13 as-isolated, partially metallated, SOD1 variant enzymes using hydrogen-deuterium exchange. We identified a shared property of these familial amyotrophic lateral sclerosis-related SOD1 variants, namely structural...

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Identifiers

PMID: 19635794
DOI: 10.1074/jbc.M109.023945
PMCID: PMC2781497

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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