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Article

Decitabine inhibits the cell growth of cholangiocarcinoma in cultured cell lines and mouse xenografts

4 Sept 2014

Abstract excerpt

Decitabine (DAC), an inhibitor of DNA methyltransferase, demonstrates antitumor activities in various types of cancer. However, its therapeutic potential for cholangiocarcinoma (CCA), one of the most aggressive gastrointestinal malignancies, remains to be explored. The present study investigated the antiproliferative effects of DAC on CCA cells in vitro and in vivo. Human CCA cell lines, TFK‑1 and QBC939, were...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
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Identifiers

PMID: 25295073
DOI: 10.3892/ol.2014.2499

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