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Article

Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase.

The Journal of biological chemistry - 21 Nov 2014

Sinha Akesh, Köhrer Caroline, Weber Michael H W, Masuda Isao, Mootha Vamsi K, Hou Ya-Ming, RajBhandary Uttam L

Abstract excerpt

N-Formylation of initiator methionyl-tRNA (Met-tRNA(Met)) by methionyl-tRNA formyltransferase (MTF) is important for translation initiation in bacteria, mitochondria, and chloroplasts. Unlike all other translation systems, the metazoan mitochondrial system is unique in using a single methionine tRNA (tRNA(Met)) for both initiation and elongation. A portion of Met-tRNA(Met) is formylated for initiation, whereas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25288793
DOI: 10.1074/jbc.M114.610626
PMCID: PMC4239624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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