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Article

An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase.

Human molecular genetics - 15 Jul 2015

Hinttala Reetta, Sasarman Florin, Nishimura Tamiko, Antonicka Hana, Brunel-Guitton Catherine, Schwartzentruber Jeremy, Fahiminiya Somayyeh, Majewski Jacek, Faubert Denis, Ostergaard Elsebet, Smeitink Jan A, Shoubridge Eric A

Abstract excerpt

Protein synthesis in mitochondria is initiated by formylmethionyl-tRNA(Met) (fMet-tRNA(Met)), which requires the activity of the enzyme MTFMT to formylate the methionyl group. We investigated the molecular consequences of mutations in MTFMT in patients with Leigh syndrome or cardiomyopathy. All p...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25911677
DOI: 10.1093/hmg/ddv149
PMCID: PMC4476453

Genes

MTFMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25911677-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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