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Article

SMYD3 promotes the epithelial–mesenchymal transition in breast cancer

23 Nov 2018

Abstract excerpt

SMYD3 is a methylase previously linked to cancer cell invasion and migration. Here we show that SMYD3 favors TGFβ-induced epithelial-mesenchymal transition (EMT) in mammary epithelial cells, promoting mesenchymal and EMT transcription factors expression. SMYD3 directly interacts with SMAD3 but it is unnecessary for SMAD2/3 phosphorylation and nuclear translocation. Conversely, SMYD3 is indispensable for SMAD3...

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PMID: 30544196
DOI: 10.1093/nar/gky1221

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