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Article

Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.

Cell reports - 9 Oct 2014

Fernandez Patricia, Scaffidi Paola, Markert Elke, Lee Ji-Hyeon, Rane Sushil, Misteli Tom

Abstract excerpt

Advanced age and DNA damage accumulation are prominent risk factors for cancer. The premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) provides a unique opportunity for studying the interplay between DNA damage and aging-associated tumor mechanisms, given that HGPS patients do not develop tumors despite elevated levels of DNA damage. Here, we have used HGPS patient cells to identify a protective...

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Source

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Identifiers

PMID: 25284786
DOI: 10.1016/j.celrep.2014.08.069
PMCID: PMC4194066

Genes

BRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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