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Article

Do viral proteins possess unique biophysical features?

Trends in biochemical sciences - 1 Feb 2009

Tokuriki Nobuhiko, Oldfield Christopher J, Uversky Vladimir N, Berezovsky Igor N, Tawfik Dan S

Abstract excerpt

Natural selection shapes the sequence, structure and biophysical properties of proteins to fit their environment. We hypothesize that highly thermostable proteins and viral proteins represent two opposing adaptation strategies. Thermostable proteins are highly compact and possess well-packed hydrophobic cores and intensely charged surfaces. By contrast, viral proteins, and RNA viral proteins in particular,...

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PMID: 19062293
DOI: 10.1016/j.tibs.2008.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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