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Article

Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation.

PLoS genetics - 1 Oct 2014

Lindsay Allia K, Morales Diana K, Liu Zhongle, Grahl Nora, Zhang Anda, Willger Sven D, Myers Lawrence C, Hogan Deborah A

Abstract excerpt

Candida albicans biofilm formation is a key virulence trait that involves hyphal growth and adhesin expression. Pyocyanin (PYO), a phenazine secreted by Pseudomonas aeruginosa, inhibits both C. albicans biofilm formation and development of wrinkled colonies. Using a genetic screen, we identified two mutants, ssn3Δ/Δ and ssn8Δ/Δ, which continued to wrinkle in the presence of PYO. Ssn8 is a cyclin-like protein and...

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Identifiers

PMID: 25275466
DOI: 10.1371/journal.pgen.1004567
PMCID: PMC4183431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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