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P and M gene junction is the optimal insertion site in Newcastle disease virus vaccine vector for foreign gene expression

2 Oct 2014

Abstract excerpt

Newcastle disease virus (NDV) has been developed as a vector for vaccine and gene therapy purposes. However, the optimal insertion site for foreign gene expression remained to be determined. In the present study, we inserted the green fluorescence protein (GFP) gene into five different intergenic regions of the enterotropic NDV VG/GA vaccine strain using reverse genetics technology. The rescued recombinant...

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PMID: 25274858
DOI: 10.1099/vir.0.068437-0

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