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Article

Construction of Recombinant Newcastle Disease Virus Italien Strain for Oncolytic Virotherapy of Tumors

28 Feb 2012

Abstract excerpt

Newcastle disease virus (NDV) is a naturally oncolytic virus that has been shown to be safe and effective for cancer therapy. Tumor virotherapy using NDV emerged in the 1950s and has advanced more recently by the increased availability of reverse genetics technology. In this study, we constructed a reverse genetics system based on the virulent and oncolytic NDV Italien strain, and generated two recombinant NDVs...

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PMID: 22372930
DOI: 10.1089/hum.2011.207

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