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Methionine restriction slows down senescence in human diploid fibroblasts

1 Oct 2014

Abstract excerpt

Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant...

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PMID: 25273919
DOI: 10.1111/acel.12266

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