Article
Prevalence of subtype-related polymorphisms associated with in vitro resistance to attachment inhibitor BMS-626529 in HIV-1 'non-B'-infected patients.
The Journal of antimicrobial chemotherapy - 1 Jun 2012
Charpentier Charlotte, Larrouy Lucile, Visseaux Benoit, Landman Roland, Levittas Marine, Storto Alexandre, Damond Florence, Yazdanpanah Yazdan, Yeni Patrick, Brun-Vézinet Françoise, Descamps Diane
Abstract excerpt
OBJECTIVES: BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. Mutations selected during in vitro experiments with BMS-626529 are located in the gp120 region: L116P, A204D, M426L, M434I-V506M and M475I. A differential antiviral activity of BMS-626529 was observed depending of the viral subtype. The aim of our study was to assess the prevalence of subtype-related...
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