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Article

Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.

The Journal of pathology - 1 Jan 2015

Tumiati Manuela, Hemmes Annabrita, Uusivirta Sanna, Koopal Sonja, Kankainen Matti, Lehtonen Eero, Kuznetsov Sergey G

Abstract excerpt

Germline mutations in RAD51C predispose to breast and ovarian cancers. However, the mechanism of RAD51C-mediated carcinogenesis is poorly understood. We previously reported a first-generation Rad51c-knock-out mouse model, in which a spontaneous loss of both Rad51c and Trp53 together resulted in a high incidence of sebaceous carcinomas, particularly in preputial glands. Here we describe a second-generation mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25270124
DOI: 10.1002/path.4455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Rad51c accelerates tumourigenesis in sebaceous glands of Trp53-mutant mice.PMID 25270124Read ↗

Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.Semantic proximity Read ↗

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Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.Semantic proximity Read ↗

c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 AxisSemantic proximity Read ↗

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