Article
FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab and chemotherapy.
Blood - 11 Jan 2018
Mottok Anja, Jurinovic Vindi, Farinha Pedro, Rosenwald Andreas, Leich Ellen, Ott German, Horn Heike, Klapper Wolfram, Boesl Michael, Hiddemann Wolfgang, Steidl Christian, Connors Joseph M, Sehn Laurie H, Gascoyne Randy D, Hoster Eva, Weigert Oliver, Kridel Robert
Abstract excerpt
Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease, yet prognostication relies predominantly on clinical tools. We recently demonstrated that integration of mutation status of 7 genes, including EZH2 and MEF2B, improves risk stratification. We mined gene expression data to uncover genes that are differentially expressed in EZH2- and MEF2B-mutated cases. We focused on FOXP1 and...
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