Article
A polymorphism in HLA-G modifies statin benefit in asthma.
The pharmacogenomics journal - 1 Jun 2015
Naidoo D, Wu A C, Brilliant M H, Denny J, Ingram C, Kitchner T E, Linneman J G, McGeachie M J, Roden D M, Shaffer C M, Shah A, Weeke P, Weiss S T, Xu H, Medina M W
Abstract excerpt
Several reports have shown that statin treatment benefits patients with asthma; however, inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3'UTR that is associated with asthma risk, modulates miRNA binding. We report that statins upregulate mir-148b and 152, and affect...
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