Article
Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
The Journal of allergy and clinical immunology - 1 Jun 2013
Nicodemus-Johnson Jessie, Laxman Bharathi, Stern Randi K, Sudi Jyotsna, Tierney Courtney N, Norwick Lourdes, Hogarth Douglas K, McConville John F, Naureckas Edward T, Sperling Anne I, Solway Julian, Krishnan Jerry A, Nicolae Dan L, White Steven R, Ober Carole
Abstract excerpt
BACKGROUND: We previously reported an interaction between maternal asthma and the child's HLA-G genotype on the child's subsequent risk for asthma. The implicated single nucleotide polymorphism at +3142 disrupted a target site for the microRNA (miR)-152 family. We hypothesized that the interaction effect might be mediated by these miRs. OBJECTIVE: The objective of this study was to test this hypothesis in adults...
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