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Prostaglandin E <sub>2</sub> promotes <i> <scp>MYCN</scp> </i> non‐amplified neuroblastoma cell survival <i>via</i> β‐catenin stabilization

30 Sept 2014

Abstract excerpt

Amplification of MYCN is the most well-known prognostic marker of neuroblastoma risk classification, but still is only observed in 25% of cases. Recent evidence points to the cyclic adenosine monophosphate (cAMP) elevating ligand prostaglandin E2 (PGE2 ) and β-catenin as two novel players in neuroblastoma. Here, we aimed to define the potential role of PGE2 and cAMP and its potential interplay with β-catenin,...

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PMID: 25266063
DOI: 10.1111/jcmm.12418

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