Article
Wnt signalling drives context-dependent differentiation or proliferation in neuroblastoma
2018-01-12
Abstract excerpt
Neuroblastoma is one of the commonest and deadliest solid tumours of childhood, and is thought to result from disrupted differentiation of the developing sympathoadrenergic lineage of the neural crest. Neuroblastoma exhibits intra-and intertumoural heterogeneity, with high risk tumours characterised by poor differentiation, which can be attributable to MYCN-mediated repression of genes involved in neuronal differe...
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Identifiers and source
- Literature Corpus work
- c92617ff-8197-5ff7-afe7-7ea512e8d4af
- DOI
- 10.1101/236745