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Article

Mutations in the testis-specific enhancer of SOX9 in the SRY independent sex-determining mechanism in the genus Tokudaia.

PloS one - 1 Jan 2014

Kimura Ryutaro, Murata Chie, Kuroki Yoko, Kuroiwa Asato

Abstract excerpt

SRY (sex-determining region Y) is widely conserved in eutherian mammals as a sex-determining gene located on the Y chromosome. SRY proteins bind to the testis-specific enhancer of SOX9 (TES) with SF1 to upregulate SOX9 expression in undifferentiated gonads of XY embryos of humans and mice. The core region within TES, named TESCO, is an important enhancer for mammalian sex determination. We show that TESCO of the...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sex Determination Processes

Share to Sex-Determining Region Y Protein

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Share to Testis

Share to Y Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 25265165
DOI: 10.1371/journal.pone.0108779
PMCID: PMC4181316

Genes

SRY
SOX9
TES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in the testis-specific enhancer of SOX9 in the SRY independent sex-determining mechanism in the genus Tokudaia.PMID 25265165Read ↗

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<i>Sry</i>: the master switch in mammalian sex determinationSemantic proximity Read ↗

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