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Article

Sox9 gene regulation and the loss of the XY/XX sex-determining mechanism in the mole vole Ellobius lutescens.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Jan 2012

Bagheri-Fam Stefan, Sreenivasan Rajini, Bernard Pascal, Knower Kevin C, Sekido Ryohei, Lovell-Badge Robin, Just Walter, Harley Vincent R

Abstract excerpt

In most mammals, the Y chromosomal Sry gene initiates testis formation within the bipotential gonad, resulting in male development. SRY is a transcription factor and together with SF1 it directly up-regulates the expression of the pivotal sex-determining gene Sox9 via a 1.3-kb cis-regulatory element (TESCO) which contains an evolutionarily conserved region (ECR) of 180 bp. Remarkably, several rodent species...

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Identifiers

PMID: 22215485
DOI: 10.1007/s10577-011-9269-5

Genes

SRY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sox9 gene regulation and the loss of the XY/XX sex-determining mechanism in the mole vole Ellobius lutescens.PMID 22215485Read ↗

Mutations in the testis-specific enhancer of SOX9 in the SRY independent sex-determining mechanism in the genus Tokudaia.Semantic proximity Read ↗

Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination.Semantic proximity Read ↗

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.Semantic proximity Read ↗

Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex DeterminationSemantic proximity Read ↗

Sox9 induces testis development in XX transgenic mice.Semantic proximity Read ↗

Mutations of the SRY-responsive enhancer of SOX9 are uncommon in XY gonadal dysgenesis.Semantic proximity Read ↗

SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degreesSemantic proximity Read ↗

A single-nucleotide enhancer mutation overrides chromosomal sex to drive XX male development.Semantic proximity Read ↗

Interactions between SRY and SOX genes in mammalian sex determinationSemantic proximity Read ↗

Sry and Sox9: mammalian testis-determining genesSemantic proximity Read ↗

A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse.Semantic proximity Read ↗

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.Semantic proximity Read ↗

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