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Article

Substrate rescue of DNA polymerase β containing a catastrophic L22P mutation.

Biochemistry - 15 Apr 2014

Kirby Thomas W, Derose Eugene F, Beard William A, Shock David D, Wilson Samuel H, London Robert E

Abstract excerpt

DNA polymerase (pol) β is a multidomain enzyme with two enzymatic activities that plays a central role in the overlapping base excision repair and single-strand break repair pathways. The high frequency of pol β variants identified in tumor-derived tissues suggests a possible role in the progress...

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Identifiers

PMID: 24655288
DOI: 10.1021/bi5001855
PMCID: PMC4004254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24655288-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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