Article
Evolutionary strategy for systemic therapy of metastatic breast cancer: balancing response with suppression of resistance.
Women's health (London, England) - 1 Jul 2014
Kam Yoonseok, Das Tuhin, Minton Susan, Gatenby Robert A
Abstract excerpt
Conventional systemic therapy for disseminated breast cancer is based on the general assumption that the greatest patient benefit is achieved by killing the maximum number of tumor cells. While this strategy often achieves a significant reduction in tumor burden, most patients with metastatic breast cancer ultimately die from their disease as therapy fails because tumor cells evolve resistance. We propose that...
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