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Article

Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.

The Journal of biological chemistry - 21 Nov 2014

Takahashi Shunji, Nagano Shingo, Nogawa Toshihiko, Kanoh Naoki, Uramoto Masakazu, Kawatani Makoto, Shimizu Takeshi, Miyazawa Takeshi, Shiro Yoshitsugu, Osada Hiroyuki

Abstract excerpt

Numerous cytochrome P450s are involved in secondary metabolite biosynthesis. The biosynthetic gene cluster for reveromycin A (RM-A), which is a promising lead compound with anti-osteoclastic activity, also includes a P450 gene, revI. To understand the roles of P450revI, we comprehensively charact...

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PMID: 25258320
DOI: 10.1074/jbc.M114.598391
PMCID: PMC4239600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25258320-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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