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Article

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

British journal of haematology - 1 Jan 2015

Mansour Marc R, Reed Casie, Eisenberg Amy R, Tseng Jen-Chieh, Twizere Jean-Claude, Daakour Sarah, Yoda Akinori, Rodig Scott J, Tal Noa, Shochat Chen, Berezovskaya Alla, DeAngelo Daniel J, Sallan Stephen E, Weinstock David M, Izraeli Shai, Kung Andrew L, Kentsis Alex, Look A Thomas

Abstract excerpt

Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-indep...

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Identifiers

PMID: 25256574
DOI: 10.1111/bjh.13115
PMCID: PMC4303513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25256574-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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