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Article

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.

Blood - 3 Jul 2014

Shochat Chen, Tal Noa, Gryshkova Vitalina, Birger Yehudit, Bandapalli Obul R, Cazzaniga Giovanni, Gershman Nava, Kulozik Andreas E, Biondi Andrea, Mansour Marc R, Twizere Jean-Claude, Muckenthaler Martina U, Ben-Tal Nir, Constantinescu Stefan N, Bercovich Dani, Izraeli Shai

Abstract excerpt

Gain-of-function somatic mutations introducing cysteines to either the extracellular or to the transmembrane domain (TMD) in interleukin-7 receptor α (IL7R) or cytokine receptor-like factor 2 (CRLF2) have been described in acute lymphoblastic leukemias. Here we report noncysteine in-frame mutations in IL7R and CRLF2 located in a region of the TMD closer to the cytosolic domain. Biochemical and functional assays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Cytokine

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Source

Identifiers

PMID: 24787007
DOI: 10.1182/blood-2013-10-529685

Genes

CRLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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