Article
Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1).
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Sept 2009
Corti Stefania, Nizzardo Monica, Nardini Martina, Donadoni Chiara, Salani Sabrina, Del Bo Roberto, Papadimitriou Dimitra, Locatelli Federica, Mezzina Nicoletta, Gianni Francesca, Bresolin Nereo, Comi Giacomo P
Abstract excerpt
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal form of infantile motoneuron disease. There is currently no effective treatment, although motor neuron replacement is a possible therapeutic strategy. We transplanted purified motor neurons into the spinal cord of nmd mice, an animal model of SMARD1. We also administered pharmacological treatment targeting the induction of axonal growth...
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