Article
Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014
AbouHaidar Mounir Georges, Venkataraman Srividhya, Golshani Ashkan, Liu Bolin, Ahmad Tauqeer
Abstract excerpt
The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid associated with rice yellow mottle virus codes for a 16-kDa highly basic protein using novel modalities for coding, translation, and gene expression. This CCC RNA is the smallest among all known viroids and virusoids and the only one that codes proteins. Its sequence possesses an internal ribosome entry site and is...
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