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Article

Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014

Herzik Mark A, Jonnalagadda Rohan, Kuriyan John, Marletta Michael A

Abstract excerpt

Heme-nitric oxide/oxygen (H-NOX) binding domains are a recently discovered family of heme-based gas sensor proteins that are conserved across eukaryotes and bacteria. Nitric oxide (NO) binding to the heme cofactor of H-NOX proteins has been implicated as a regulatory mechanism for processes ranging from vasodilation in mammals to communal behavior in bacteria. A key molecular event during NO-dependent activation...

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Identifiers

PMID: 25253889
DOI: 10.1073/pnas.1416936111
PMCID: PMC4210026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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