Article
Steatohepatitic hepatocellular Carcinoma:A new approach to classifying morphological subtypes of hepatocellular carcinoma.
Human pathology - 1 Jul 2024
Soon Gwyneth S T, Callea Francesco, Burt Alastair D, Cook Sam, Terracciano Luigi, Ercan Caner, Dienes Hans-Peter, Goodman Zachary D, Roberts Eve A, Clouston Andrew D, Gouw Annette S H, Kleiner David E, Park Young Nyun, Chung Taek, Schirmacher Peter, Tiniakos Dina, Dimopoulou Konstantina, Weber Achim, Endhardt Katharina, Torbenson Michael
Abstract excerpt
Histological subtyping of hepatocellular carcinoma (HCC) is challenging in the presence of histological heterogeneity, where distinctly different morphological patterns are present within the same tumor. Current approaches rely on percent cut-offs. We hypothesized that morphologic intratumor heterogeneity is a non-random biological feature and that incorporating recurrent patterns would improve histological...
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