Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis.

doi:10.1086/600141

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Article

Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis.

The Journal of infectious diseases - 1 Aug 2009

Murphy Ellen, Andrew Lubomira, Lee Kwok-Leung, Dilts Deborah A, Nunez Lorna, Fink Pamela S, Ambrose Karita, Borrow Ray, Findlow Jamie, Taha Muhamed-Kheir, Deghmane Ala-Eddine, Kriz Paula, Musilek Martin, Kalmusova Jitka, Caugant Dominique A, Alvestad Torill, Mayer Leonard W, Sacchi Claudio T, Wang Xin, Martin Diana, von Gottberg Anne, du Plessis Mignon, Klugman Keith P, Anderson Annaliesa S, Jansen Kathrin U, Zlotnick Gary W, Hoiseth Susan K

Abstract excerpt

BACKGROUND: Recombinant forms of Neisseria meningitidis human factor H binding protein (fHBP) are undergoing clinical trials in candidate vaccines against invasive meningococcal serogroup B disease. We report an extensive survey and phylogenetic analysis of the diversity of fhbp genes and predicted protein sequences in invasive clinical isolates obtained in the period 2000-2006. METHODS: Nucleotide sequences of...

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PMID: 19534597
DOI: 10.1086/600141

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