Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010-2014.

doi:10.1080/21645515.2024.2378537

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Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010-2014.

Human vaccines & immunotherapeutics - 31 Dec 2024

Efron Adriana, Brozzi Alessandro, Biolchi Alessia, Bodini Margherita, Giuliani Maria, Guidotti Silvia, Lorenzo Federico, Moscoloni María Alicia, Muzzi Alessandro, Nocita Florencia, Pizza Mariagrazia, Rappuoli Rino, Tomei Sara, Vidal Gabriela, Vizzotti Carla, Campos Josefina, Sorhouet Pereira Cecilia

Abstract excerpt

Meningococcal (Neisseria meningitidis) serogroup B (MenB) strain antigens are diverse and a limited number of strains can be evaluated using the human serum bactericidal antibody (hSBA) assay. The genetic Meningococcal Antigen Typing System (gMATS) was developed to predict the likelihood of coverage for large numbers of isolates by the 4CMenB vaccine, which includes antigens Neisseria adhesin A (NadA), Neisserial...

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PMID: 39037011
DOI: 10.1080/21645515.2024.2378537

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