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Article

The combination of ceftaroline plus daptomycin allows for therapeutic de-escalation and daptomycin sparing against MRSA.

The Journal of antimicrobial chemotherapy - 1 Feb 2015

Barber Katie E, Werth Brian J, Rybak Michael J

Abstract excerpt

OBJECTIVES: We previously demonstrated that ceftaroline enhances daptomycin against MRSA in vitro. However, prolonged combination therapy is clinically undesirable and possibly unnecessary. The purpose of this study was to determine if this combination could be de-escalated to a single agent without compromising efficacy. METHODS: We investigated the following simulated regimens against two clinical,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25246437
DOI: 10.1093/jac/dku378
PMCID: PMC4291233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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