Article
Generating Genotype-Specific Aminoglycoside Combinations with Ceftazidime/Avibactam for KPC-Producing Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy - 17 Aug 2021
Huang Yanqin, Sokolowski Karol, Rana Amisha, Singh Nidhi, Wang Jiping, Chen Ke, Lang Yinzhi, Zhou Jieqiang, Kadiyala Neera, Krapp Fiorella, Ozer Egon A, Hauser Alan R, Li Jian, Bulitta Jürgen B, Bulman Zackery P
Abstract excerpt
Antibiotic combinations, including ceftazidime/avibactam (CAZ/AVI), are frequently employed to combat KPC-producing Klebsiella pneumoniae (KPC-Kp), though such combinations have not been rationally optimized. Clinical KPC-Kp isolates with common genes encoding aminoglycoside-modifying enzymes (AMEs), aac(6')-Ib' or aac(6')-Ib, were used in static time-kill assays (n = 4 isolates) and the hollow-fiber infection...
Topics
- Aminoglycosides
- Animals
- Anti-Bacterial Agents
- Azabicyclo Compounds
- Ceftazidime
- Drug Combinations
- Genotype
- Klebsiella Infections
- Klebsiella pneumoniae
- Mice
- Microbial Sensitivity Tests
- beta-Lactamases