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Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity

1 Nov 2010

Abstract excerpt

Ceftaroline fosamil is a novel cephalosporin with broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. The activity of ceftaroline against MRSA is attributed to its ability to bind to penicillin-binding protein (PBP) 2a with high affinity and inhibit the...

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Share to Antibiotic Resistance in Bacteria
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PMID: 21115457
DOI: 10.1093/jac/dkq251

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