Article
Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture.
American journal of human genetics - 2 Oct 2014
Bhatia Gaurav, Tandon Arti, Patterson Nick, Aldrich Melinda C, Ambrosone Christine B, Amos Christopher, Bandera Elisa V, Berndt Sonja I, Bernstein Leslie, Blot William J, Bock Cathryn H, Caporaso Neil, Casey Graham, Deming Sandra L, Diver W Ryan, Gapstur Susan M, Gillanders Elizabeth M, Harris Curtis C, Henderson Brian E, Ingles Sue A, Isaacs William, De Jager Phillip L, John Esther M, Kittles Rick A, Larkin Emma, McNeill Lorna H, Millikan Robert C, Murphy Adam, Neslund-Dudas Christine, Nyante Sarah, Press Michael F, Rodriguez-Gil Jorge L, Rybicki Benjamin A, Schwartz Ann G, Signorello Lisa B, Spitz Margaret, Strom Sara S, Tucker Margaret A, Wiencke John K, Witte John S, Wu Xifeng, Yamamura Yuko, Zanetti Krista A, Zheng Wei, Ziegler Regina G, Chanock Stephen J, Haiman Christopher A, Reich David, Price Alkes L
Abstract excerpt
The extent of recent selection in admixed populations is currently an unresolved question. We scanned the genomes of 29,141 African Americans and failed to find any genome-wide-significant deviations in local ancestry, indicating no evidence of selection influencing ancestry after admixture. A recent analysis of data from 1,890 African Americans reported that there was evidence of selection in African Americans...
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