Article
Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?
European cytokine network - 1 Jan 2000
Ouyang Qin, Wagner Wolfgang M, Wikby Anders, Remarque Ed, Pawelec Graham
Abstract excerpt
The elderly suffer from an increased incidence of infectious disease, accompanied by increased morbidity and mortality. Interferon-gamma plays an important role in defense against intracellular pathogens such as mycobacteria and viruses. A reduced capacity to produce this cytokine in the elderly, as demonstrated by our findings of significant decreases in IFN-gamma production in vitro on stimulation with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.