Article
Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.
Molecular and cellular biochemistry - 1 Jan 2015
Xia Yong, Khoi Pham Ngoc, Yoon Hyun Joong, Lian Sen, Joo Young Eun, Chay Kee Oh, Kim Kyung Keun, Jung Young Do
Abstract excerpt
Piperine, a kind of natural alkaloid found in peppers, has been reported to exhibit anti-oxidative and anti-tumor activities, both in vitro and in vivo. Interleukin-6 (IL-6) is an important cytokine that activates the signal transduction, promotes tumor cell metastasis, and induces malignancy, including in gastric cancer. However, the effects of piperine on IL-6 expression in gastric cancer cells have not yet...
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