Article
DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.
American journal of respiratory cell and molecular biology - 1 Aug 2016
Dougherty Gerard W, Loges Niki T, Klinkenbusch Judith A, Olbrich Heike, Pennekamp Petra, Menchen Tabea, Raidt Johanna, Wallmeier Julia, Werner Claudius, Westermann Cordula, Ruckert Christian, Mirra Virginia, Hjeij Rim, Memari Yasin, Durbin Richard, Kolb-Kokocinski Anja, Praveen Kavita, Kashef Mohammad A, Kashef Sara, Eghtedari Fardin, Häffner Karsten, Valmari Pekka, Baktai György, Aviram Micha, Bentur Lea, Amirav Israel, Davis Erica E, Katsanis Nicholas, Brueckner Martina, Shaposhnykov Artem, Pigino Gaia, Dworniczak Bernd, Omran Heymut
Abstract excerpt
Primary ciliary dyskinesia (PCD) is a recessively inherited disease that leads to chronic respiratory disorders owing to impaired mucociliary clearance. Conventional transmission electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in respiratory cilia but is not useful in approximately 30% of PCD cases, which have normal ciliary ultrastructure. DNAH11 mutations are a common...
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