Article

Successful Liver transduction by Re-administration of Different Adeno-Associated Virus Vector Serotypes in Mice

2022-10-22

Abstract excerpt

Intravenous administration of adeno-associated virus (AAV) vector is a promising gene therapy approach for monogenic diseases. However, re-administration of the same AAV serotype is impossible due to the induction of anti-AAV neutralizing antibodies (NAbs). Here we examined the feasibility of re-administration of AAV vectors to change the serotypes. We administered AAV3B, AAV5, or AAV8 vectors targeting the liver...

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Literature Corpus work: e59f5d91-17d7-57c1-8a4b-d3f8dc1ab28b
DOI: 10.1101/2022.10.21.513281

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