Article
Loss of ATP-dependent lysine uptake in the vacuolar membrane vesicles of Saccharomyces cerevisiae ypq1∆ mutant.
Bioscience, biotechnology, and biochemistry - 1 Jan 2014
Sekito Takayuki, Nakamura Kyosuke, Manabe Kunio, Tone Junichi, Sato Yumika, Murao Nami, Kawano-Kawada Miyuki, Kakinuma Yoshimi
Abstract excerpt
Saccharomyces cerevisiae Ypq1p is a vacuolar membrane protein of the PQ-loop protein family. We found that ATP-dependent uptake activities of amino acids by vacuolar membrane vesicles were impaired by ypq1∆ mutation. Loss of lysine uptake was most remarkable, and the uptake was recovered by overproduction of Ypq1p. Ypq1p is thus involved in transport of amino acids into vacuoles.
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