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Article

Analysis of the pore of the unusual major intrinsic protein channel, yeast Fps1p.

The Journal of biological chemistry - 28 Sept 2001

Bill R M, Hedfalk K, Karlgren S, Mullins J G, Rydström J, Hohmann S

Abstract excerpt

Fps1p is a glycerol efflux channel from Saccharomyces cerevisiae. In this atypical major intrinsic protein neither of the signature NPA motifs of the family, which are part of the pore, is preserved. To understand the functional consequences of this feature, we analyzed the pseudo-NPA motifs of Fps1p by site-directed mutagenesis and assayed the resultant mutant proteins in vivo. In addition, we took advantage of...

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PMID: 11445582
DOI: 10.1074/jbc.M105045200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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