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Article

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2014

Läubli Heinz, Pearce Oliver M T, Schwarz Flavio, Siddiqui Shoib S, Deng Lingquan, Stanczak Michal A, Deng Liwen, Verhagen Andrea, Secrest Patrick, Lusk Chrissy, Schwartz Ann G, Varki Nissi M, Bui Jack D, Varki Ajit

Abstract excerpt

Certain pathogenic bacteria are known to modulate the innate immune response by decorating themselves with sialic acids, which can engage the myelomonocytic lineage inhibitory receptor Siglec-9, thereby evading immunosurveillance. We hypothesized that the well-known up-regulation of sialoglycocon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25225409
DOI: 10.1073/pnas.1409580111
PMCID: PMC4191788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25225409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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