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Article

Pathway Analysis of MicroRNA Expression Profile during Murine Osteoclastogenesis

15 Sept 2014

Abstract excerpt

To design novel therapeutics against bone loss, understanding the molecular mechanisms regulating osteoclastogenesis is critical. Osteoclast formation and function are tightly regulated by transcriptional, post-transcriptional and post-translational mechanisms. This stringent regulation is crucial to prevent excessive or insufficient bone resorption and to maintain bone homeostasis. microRNAs (miRNAs) are key...

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PMID: 25222202
DOI: 10.1371/journal.pone.0107262

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