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Article

Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation.

Medical hypotheses - 1 Nov 2014

Finley Jahahreeh

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by an accelerated aging phenotype and an average life span of 13years. Patients typically exhibit extensive pathophysiological vascular alterations, eventually resulting in death from stroke or myocardial infarc...

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Source

Identifiers

PMID: 25216752
DOI: 10.1016/j.mehy.2014.08.016

Genes

LMNA
SRSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25216752-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation.PMID 25216752Read ↗

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Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations.Semantic proximity Read ↗

MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromesSemantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.Semantic proximity Read ↗

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MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients' Cells.Semantic proximity Read ↗

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