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Article

Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation.

Medical hypotheses - 1 Nov 2014

Finley Jahahreeh

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by an accelerated aging phenotype and an average life span of 13years. Patients typically exhibit extensive pathophysiological vascular alterations, eventually resulting in death from stroke or myocardial infarction. A silent point mutation at position 1824 (C1824T) of the LMNA gene, generating a truncated form of lamin A...

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Source

Identifiers

PMID: 25216752
DOI: 10.1016/j.mehy.2014.08.016

Genes

LMNA
SRSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alteration of splice site selection in the LMNA gene and inhibition of progerin production via AMPK activation.PMID 25216752Read ↗

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Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations.Semantic proximity Read ↗

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