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Article

High Thymidylate Synthase Expression in Colorectal Cancer with Microsatellite Instability: Implications for Chemotherapeutic Strategies

1 Jun 2005

Abstract excerpt

UNLABELLED: Colon cancers displaying microsatellite instability (MSI) are clinically less aggressive. Based on in vitro studies and recent clinical data, cancers displaying MSI do not respond to 5-fluorouracil (5-FU). The reasons why MSI tumors are clinically less aggressive and do not respond to 5-FU-based therapies have not been fully elucidated. PURPOSE: We investigated biomolecular markers in an attempt to...

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PMID: 15930362
DOI: 10.1158/1078-0432.ccr-05-0141

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