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Germline deletions in the EPCAM gene as a cause of Lynch syndrome – literature review

12 Aug 2013

Abstract excerpt

Lynch syndrome (clinically referred to as HNPCC - Hereditary Non-Polyposis Colorectal Cancer) is a frequent, autosomal, dominantly-inherited cancer predisposition syndrome caused by various germline alterations that affect DNA mismatch repair genes, mainly MLH1 and MSH2. Patients inheriting this predisposition are susceptible to colorectal, endometrial and other extracolonic tumors. It has recently been shown...

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PMID: 23938213
DOI: 10.1186/1897-4287-11-9

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