Article
The molecular basis of EPCAM expression loss in Lynch syndrome-associated tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2012
Huth Cathrin, Kloor Matthias, Voigt Anita Y, Bozukova Gergana, Evers Christina, Gaspar Harald, Tariverdian Mirjam, Schirmacher Peter, von Knebel Doeberitz Magnus, Bläker Hendrik
Abstract excerpt
Germline deletions affecting the epithelial cell adhesion molecule (EPCAM) gene lead to silencing of MSH2 and cause Lynch syndrome. We have recently reported that lack of EPCAM expression occurs in many, but not all tumors from Lynch syndrome patients with EPCAM germline deletions. The difference...
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