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Article

Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.

Circulation. Cardiovascular genetics - 1 Dec 2014

Perrin Mark J, Adler Arnon, Green Sharon, Al-Zoughool Foad, Doroshenko Petro, Orr Nathan, Uppal Shaheen, Healey Jeff S, Birnie David, Sanatani Shubhayan, Gardner Martin, Champagne Jean, Simpson Chris, Ahmad Kamran, van den Berg Maarten P, Chauhan Vijay, Backx Peter H, van Tintelen J Peter, Krahn Andrew D, Gollob Michael H

Abstract excerpt

BACKGROUND: J-wave ECG patterns are associated with an increased risk of sudden arrhythmic death, and experimental evidence supports a transient outward current (I(to))-mediated mechanism of J-wave formation. This study aimed to determine the frequency of genetic mutations in genes encoding the I...

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Source

Identifiers

PMID: 25214526
DOI: 10.1161/CIRCGENETICS.114.000623

Genes

KCND2
KCNJ8
KCNA4
KCND3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25214526-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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