Article
Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function.
Cardiovascular research - 1 Nov 2014
Schlipp Angela, Schinner Camilla, Spindler Volker, Vielmuth Franziska, Gehmlich Katja, Syrris Petros, Mckenna William J, Dendorfer Andreas, Hartlieb Eva, Waschke Jens
Abstract excerpt
AIMS: We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. METHODS AND RESULTS: We studied intercalated discs of HL-1 cardiomyocytes by immunostaining of desmoglein-2...
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